Table 6 Effects of cardiovascular and renal disease on treatment effects of metformin in IPF with T2DM
| Â | Matched | Treated adjusted hazard ratio [95% CI] | p-value for interaction | |
|---|---|---|---|---|
|  | No metformin (N = 1100) | Metformin (N = 1100) | ||
Arrhythmia | Â | Â | Â | 0.41 |
 Yes | 30.64 (25.52, 36.78) | 17.07 (12.70, 22.94) | 0.49 (0.34, 0.69) |  |
 No | 16.80 (14.41, 19.57) | 7.67 (5.76, 10.21) | 0.42 (0.31, 0.60) |  |
CHF | Â | Â | Â | 0.07 |
 Yes | 30.96 (26.05, 36.79) | 21.52 (16.21, 28.55) | 0.58 (0.41, 0.81) |  |
 No | 16.04 (13.67, 18.83) | 6.64 (4.93, 8.96) | 0.39 (0.28, 0.55) |  |
PVD | Â | Â | Â | 0.39 |
 Yes | 24.12 (18.95, 30.71) | 15.00 (10.05, 22.37) | 0.56 (0.35, 0.90) |  |
 No | 19.76 (17.27, 22.59) | 9.43 (7.42, 11.98) | 0.44 (0.33, 0.58) |  |
Renal | Â | Â | Â | 0.52 |
 Yes | 25.12 (19.42, 32.50) | 15.19 (9.90, 23.29) | 0.55 (0.33, 0.90) |  |
 No | 19.72 (17.28, 22.49) | 7.32 (7.56, 12.08) | 0.44 (0.34, 0.58) |  |