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Table 1 List of the parameters varied by the optimization algorithm in order to calibrate the model to patient data, with their dimensions and allowable range of variation

From: Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation

Parameter (x)

size

ranges

Pext

100

[− 50,28.8]

kstiff

100

[− 2,1]

TOP (cmH2O)

100

[5,100] [18]

RQ

1

[0.7,0.9] [19]

VO2 (mL min−1)

1

[150,300] [19]

HB (g.l−1)

1

[90,160] [20]

Shuntanat (%)

1

[1, 2] [21]

VD (mL)

1

[60,150] [22]

  1. Pext: the extrinsic pressure acting on compartments; kstiff: the stiffness of the compartments; TOP: threshold opening pressure of the compartments; RQ: respiratory quotient; VO2: total oxygen consumption; HB: hemoglobin; Shuntanat: anatomical shunt; VD: volume of anatomical dead space
  2. Pext and Kstiff ranges were determined to provide a functional residual capacity of 2.5L for an average adult of 70 kg [23]