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Fig. 4 | Respiratory Research

Fig. 4

From: Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease

Fig. 4

The figure is an overview of the methods and analyses performed in this study. We start with three different Data sets each providing a set of genes. Using these genes and the ENCORE Method we compute for each data set a connected component in the HumanNet PPI, a Module. Next, we analyze the connectivity of these three modules in the PPI. Doing so, we can identify Interactors, genes which link different modules with each other. Performing an Enrichment analysis on these interactors reveals different Pathways, including the AGE-RAGE pathway and Focal Adhesion. This methodological workflow can be applied to any lung disease with published results

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Respiratory Research

ISSN: 1465-993X

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