Fig. 4
From: Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema
Comparison between elastase and saline instillation in control and nicotine-pretreated mice at ped3. RNAseq analysis, with significance higher than 0.05 and fold changes (FC) of 2 or higher between the elastase and saline treated lungs resulted in 839 (723 upregulated + 116 downregulated) differentially expressed genes in the control group (A left) and 516 (439 upregulated + 77 downregulated) differentially expressed genes in the nicotine group (A right). Top 10 pathways modified by upregulated genes are shown in B for the control and in C for the nicotine group. The common pathways between B and C are shown in green. Top 10 pathways (or less) modified by downregulated genes are shown in D for the control and in E for the nicotine group. Only pathways with -log(pValue) of 3 or more are shown