Transcriptomic analysis and validation reveal the pathogenesis and a novel biomarker of acute exacerbation of chronic obstructive pulmonary disease

Table 2 Demographics of independent cohort used for validation

	Control	Stable COPD	AECOPD
Samples, N	35	27	30
Age, years	67.66 ± 7.80	68.00 ± 8.00	74.17 ± 7.59
Sex	25 male, 10 female	27 male	29 male, 1 female
Smoking status	13 current, 12 former, 10 never	11 current, 11 former, 5 never	10 current, 18 former, 2 never
BMI, kg/m²	24.97 ± 3.08	22.93 ± 2.52	21.42 ± 3.22
FEV₁, %Predicted	NA	53.33 ± 14.64	54.71 ± 26.09
FEV₁/FVC ratio, %	NA	51.70 ± 11.18	49.05 ± 14.58
Basic disease	Hypertension, diabetes	Hypertension, coronary heart disease	Hypertension, coronary heart disease

COPD chronic obstructive pulmonary disease, AECOPD acute exacerbation of chronic obstructive pulmonary disease, BMI body mass index, NA not applicable

ISSN: 1465-993X