Fig. 2

STAT3 inhibition reduces the type 2 inflammatory response in IL-13 treated Tollip sufficient tracheobronchial epithelial cells. A IL-13 treatment increased activation/phosphorylation of STAT3, which was inhibited by a STAT3 inhibitor. Data was normalized to the IL-13 treatment with 0.5% DMSO. B A STAT3 inhibitor significantly reduced the levels of IL-13-induced eotaxin-3 in supernatants. P-values represent a paired student’s t-test. Data are from four healthy human donors. Each dot represents one donor. Data from one donor is the mean of three technical replicates