Table 3 HRCT characteristics and correlation with sRAGE
From: Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans
| Â | Radiological difference between healthy and COPD | sRAGE correlation within total group | |||
|---|---|---|---|---|---|
COPD patients | Healthy controls (GOLD 0) | P-value | Rho | P-value | |
LAA below -950 HU, % | 10.37 (10.59) | 2.41 (3.00) |  < 0.0001 |  − 0.241 |  < 0.0001 |
5-year change | 1.83 (4.85) |  − 0.36 (2.38) |  < 0.0001 |  − 0.187 | 0.0001 |
LAA % below -856 HU, % | 30.85 (18.77) | 10.08 (7.94) |  < 0.0001 |  − 0.186 |  < 0.0001 |
5-year change | 3.29 (9.83) | 0.75 (6.20) | 0.0036 |  − 0.115 | 0.0183 |
Perc15, HU | 934.6 (22.8) | 914.8 (17.9) |  < 0.0001 | 0.201 |  < 0.0001 |
5-year change |  − 3.65 (10.66) | 0.71 (13.06) | 0.0001 | 0.082 | 0.09 |
PRM Emphysema, % | 8.9 (10.5) | 0.9 (1.5) |  < 0.0001 |  − 0.226 |  < 0.0001 |
5-year change | 2.24 (4.85) | 0.03 (1.1) |  < 0.0001 |  − 0.217 |  < 0.0001 |
PRM Air trapping, % | 22.9 (12.2) | 9.2 (6.5) |  < 0.0001 |  − 0.147 | 0.0014 |
5-year change | 1.43 (7.64) | 0.87 (5.00) | 0.41 |  − 0.015 | 0.75 |
PRM Normal, % | 65.7 (20.5) | 88.3 (8.8) |  < 0.0001 | 0.210 |  < 0.0001 |
5-year change |  − 3.45 (9.91) |  − 0.54 (6.65) | 0.0109 | 0.109 | 0.0254 |
Pi10, mm | 2.43 (0.52) | 1.85 (0.34) |  < 0.0001 |  − 0.099 | 0.0270 |
5-year change | 0.03 (0.33) | 0.03 (0.14) | 0.96 |  − 0.033 | 0.49 |
Centrilobular emphysema | 2 (0–5) | 0 (0–3) |  < 0.0001 |  − 0.197 |  < 0.0001 |
5-year change | NA | NA | NA | NA | NA |
Paraseptal emphysema | 0 (0–2) | 0 (0–2) |  < 0.0001 |  − 0.081 | 0.07 |
5-year change | NA | NA | NA | NA | NA |