Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans

Respiratory Research

Table 2 sRAGE explaining the variation in FEV1 and quantitative and visual HRCT measurements

Change between baseline and 5-year follow-up
	FEV1		%LAA Below -950HU		Centrilobular emphysema		Pi10		Air trapping (PRM)
	R square: 0.051		R square: 0.103		R square:		R square: 0.013		R square: 0.051
	Beta	p-value	Beta	p-value	Beta	p-value	Beta	p-value	Beta	p-value
sRAGE	0.020	0.66	− 0.172	0.0003	ND	ND	− 0.033	0.50	− 0.002	0.97
Sex	− 0.204	< 0.0001	− 0.084	0.08	ND	ND	− 0.072	0.15	0.007	0.89
Age	− 0.055	0.26	− 0.060	0.23	ND	ND	0.033	0.53	− 0.108	0.0433
BMI	− 0.085	0.05	− 0.146	0.0019	ND	ND	0.037	0.46	− 0.068	0.17
Curent smoking	0.030	0.52	0.150	0.0024	ND	ND	0.014	0.79	0.142	0.0061
Pack years	− 0.079	0.08	0.098	0.0400	ND	ND	− 0.084	0.09	0.063	0.21

Beta standardized coefficient. Adjusted for age at enrollment, sex, BMI, current smoking, pack years. ND not determined (no 5-year follow-up scores done). sRAGE levels, BMI, smoking status and pack years were obtained at baseline, lung function parameters were obtained at baseline and at 5-year follow-up, statistical significant results are depicted in bold

ISSN: 1465-993X