Fig. 2

sRAGE associates with centrilobular emphysema. The levels of sRAGE were assessed in plasma using the simplified immunoprecipitation in 96-well ELISA (IPE) methodology coupled to targeted liquid chromatography-mass spectrometry (LC–MS). A The association of plasma sRAGE with centrilobular emphysema (CLE) was assessed by measuring sRAGE in plasma of 139 subjects without CLE, 85 subjects with trace CLE, 107 subjects with mild CLE, 82 subjects with moderate CLE, 60 subjects with confluent CLE and 24 subjects with advanced destructive CLE. B The association of plasma sRAGE with paraseptal emphysema (PSE) was assessed by measuring sRAGE in plasma of 299 subjects without PSE, 105 subjects with mild PSE and 93 subjects with substantial PSE. Data is shown as individuals data points and mean ± SEM. Statistical differences were tested using a Mann–Whitney U test, *p < 0.05, **p < 0.01, ***p < 0.001. The exact p-values are indicated where appropriate