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Table 2 Risk factors for all-cause mortality in CTD-ILD

From: Prediction of long-term mortality by using machine learning models in Chinese patients with connective tissue disease-associated interstitial lung disease

Variables

Unadjusted hazard ratio

Multivariable analysis

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P-value

Age, years

1.041 (1.027–1.055)

< 0.001

1.035 (1.020–1.050)

< 0.001

Subtypes of CTD

 RA

2.292 (1.539–3.413)

< 0.001

1.788 (1.162–2.750)

0.008

Baseline lung function

 DLco, %Predicted

0.982 (0.975–0.990)

 < 0.001

0.984 (0.977–0.992)

 < 0.001

Echocardiography

 RVD, mm

1.027 (1.017–1.038)

< 0.001

1.026 (1.012–1.039)

< 0.001

 RAA, cm2

1.122 (1.093–1.151)

< 0.001

1.058 (1.015–1.102)

0.007

 PASP, mmHg

1.025 (1.017–1.034)

< 0.001

1.008 (0.994–1.023)

0.275

 LVEF, %

0.949 (0.926–0.973)

< 0.001

0.971 (0.943–1.001)

0.054

Image charatern

 Honeycombing

2.167 (1.392–3.373)

0.001

1.847 (1.158–2.947)

0.010

Treatment

 Immunosuppressive agents

0.506 (0.367–0.697)

< 0.001

0.631 (0.450–0.885)

0.008

Serologic test

 CRP, mg/l

1.005 (1.002–1.008)

< 0.001

1.002 (0.998–1.006)

0.231

 BNP, pg/ml

1.000 (1.000–1.000)

< 0.001

1.000 (1.000–1.000)

0.792

 AST, U/l

1.003 (1.002–1.005)

< 0.001

1.003 (1.002–1.005)

< 0.001

 GGT, U/l

1.002 (1.001–1.003)

< 0.001

1.001 (1.000–1.002)

0.129

 ALB, g/l

0.936 (0.914–0.959)

< 0.001

0.959 (0.932–0.987)

0.004

 ILD-GAP model

1.413 (1.285–1.554)

< 0.001

  
  1. CTD connective tissue disease, RA rheumatoid arthritis, DLco carbon monoxide diffusion capacity, RVD right ventricular diameter, RAA right atrial area, PASP pulmonary artery systolic pressure, LVEF left ventricular ejection fraction, CRP C-reactive protein, BNP B-type natriuretic peptide, AST aspartate transaminase, GGT γ-Glutamyltranspeptidase, ALB albumin
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Respiratory Research

ISSN: 1465-993X

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