Table 2 Significant common functional clusters biological process related to pulmonary function by GREAT using binomial test

FEV1

 Negative regulation of phospholipid biosynthetic process

2.30E−112

2.40E−108

117

 Platelet-derived growth factor binding

1.75E−66

6.45E−63

142

 Potassium:chloride symporter activity

2.13E−59

2.62E−56

56

 Epithelial-mesenchymal cell signaling

3.35E−57

3.18E−54

127

 Decreased serum estradiol

2.18E−47

2.23E−44

49

 Low voltage-gated calcium channel activity

1.91E−44

1.41E−41

50

 cAMP response element binding protein binding

1.41E−38

5.76E−36

64

 Activation of Cdc42 GTPase activity

3.30E−36

5.30E−34

49

 Ceramide signaling pathway

3.85E−33

1.69E−30

176

 Transcription regulation by bZIP transcription factor

2.38E−29

3.61E−27

116

 Mitogen-activated protein kinase p38 binding

9.76E−16

5.81E−14

33

 Notch signaling pathway

3.93E−13

9.97E−12

115

FVC

 Activation of Cdc42 GTPase activity

5.16E−82

5.39E−78

88

 Potassium:chloride symporter activity

1.08E−73

1.99E−70

67

 Negative regulation of phospholipid biosynthetic process

1.82E−54

5.77E−52

73

 Epithelial-mesenchymal cell signaling

1.61E−45

3.29E−43

116

 Decreased serum estradiol

2.81E−43

1.92E−40

47

 Platelet-derived growth factor binding

3.14E−36

1.05E−33

106

 Low voltage-gated calcium channel activity

1.08E−35

3.33E−33

44

 Transcription regulation by bZIP transcription factor

1.57E−31

2.39E−29

125

 Notch signaling pathway

4.40E−29

1.16E−26

155

 cAMP response element binding protein binding

1.22E−19

1.05E−17

44

 Mitogen-activated protein kinase p38 binding

3.38E−17

2.04E−15

36

 Ceramide signaling pathway

1.07E−13

4.56E−12

134

FEV1/FVC

 Negative regulation of phospholipid biosynthetic process

7.31E−162

7.63E−158

164

 Platelet-derived growth factor binding

3.83E−103

1.41E−99

205

 Epithelial-mesenchymal cell signaling

2.93E−64

1.18E−61

153

 Activation of Cdc42 GTPase activity

3.00E−58

8.25E−56

74

 Low voltage-gated calcium channel activity

9.99E−55

6.14E−52

63

 Ceramide signaling pathway

5.35E−44

3.53E−41

232

 Potassium:chloride symporter activity

7.68E−43

1.89E−40

48

 Decreased serum estradiol

5.03E−36

1.55E−33

44

 cAMP response element binding protein binding

9.55E−35

1.76E−32

67

 Notch signaling pathway

4.98E−31

9.39E−29

179

 Transcription regulation by bZIP transcription factor

2.74E−27

4.16E−25

131

 Mitogen-activated protein kinase p38 binding

1.19E−21

7.41E−20

45