Table 1 Patients’ characteristics, MDD diagnosis and clinical data before surgical lung biopsy, and mortality
From: Radiological pleuroparenchymal fibroelastosis-like lesion in idiopathic interstitial pneumonias
Variables | Total | Without PPFE | With PPFE | p value |
|---|---|---|---|---|
n = 419 | n = 318 | n = 101 | ||
Age, years | 65 (59, 70) | 65 (58, 70) | 67 (61, 71) | 0.0319 |
Sex, male, n (%) | 273 (65) | 210 (66) | 63(62) | 0.5493 |
Never smokers, n (%) | 147 (35) | 102 (33) | 45 (45) | 0.0307 |
IPF, n (%) | 199 (47) | 145 (46) | 54 (53) | |
iNSIP, n (%) | 44 (11) | 41 (13) | 3 (3) | |
COP, n (%) | 5 (1) | 5 (1) | 0 (0) | |
DIP/RB-ILD, n (%) | 9 (2) | 9 (3) | 0 (0) | |
Unclassifiable IIPs, n (%) | 162 (39) | 118 (37) | 44 (44) | |
PaO2, mmHg | 83.7 (76, 90) | 83.5 (76, 90) | 85.4 (77, 92) | 0.2737 |
PaCO2, mmHg | 40.9 (39, 44) | 40.4 (38, 43) | 42.7 (39, 45) | 0.0006 |
LDH, U/mL | 225 (199, 260) | 226 (200, 264) | 219 (191, 251) | 0.0903 |
KL-6, U/mL | 1088 (671, 1763) | 1099 (677, 1894) | 1040 (571, 1540) | 0.1318 |
SP-D, ng/mL | 198 (131, 322) | 178 (118, 305) | 248 (156, 373) | 0.0013 |
%predicted FVC (%) | 82.2 (70, 94) | 83 (71, 96) | 79 (67, 91) | 0.0661 |
%predicted DLCO (%) | 67.0 (53, 83) | 66.2 (53, 81) | 70.2 (54, 83) | 0.2531 |
HRCT pattern | 0.0041 | |||
UIP | 38 (9) | 25 (8) | 13 (13) | |
Possible UIP | 226 (54) | 162 (51) | 64 (63) | |
Inconsistent with UIP | 155 (37) | 131 (41) | 24 (24) | |
HRCT findings | ||||
Emphysema | 126 (30) | 112 (35) | 14 (14) | < 0.0001 |
Honeycombing | 41 (10) | 26 (8) | 15 (15) | 0.0632 |
Deceased | 116 (28) | 76 (24) | 40 (40) | 0.0027 |