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Fig. 5 | Respiratory Research

Fig. 5

From: Prostaglandin E2 sensitizes the cough reflex centrally via EP3 receptor-dependent activation of NaV 1.8 channels

Fig. 5

Effect of pretreatment with the EP3 antagonist, L-798,106, on sulprostone-enhanced citric acid-induced cough. Pretreatment of guinea pigs with 15 μl of L-798,106 (2.5 mg/ml; n = 7 and 5 mg/ml; n = 10, i.c.v.) resulted in a dose-dependent inhibition of the sulprostone-enhanced citric acid-induced cough response compared to vehicle (n = 10). Data are plotted as a scatter graph A and a bar chart B showing mean cough ± SEM. * represent a statistically significant difference at P ≤ 0.05 when compared to vehicle pretreated animals

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Respiratory Research

ISSN: 1465-993X

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