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Table 2 Top proteins downregulated in IPF plasma compared to healthy controls

From: Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis

Gene Description Log fold change FDR
GFAP Glial fibrillary acidic protein − 3.660959317 8.20E−05
IL1RL1 Interleukin-1 receptor-like 1 − 2.634896607 0.000167
BMPR1A Bone morphogenetic protein receptor type-1A − 2.467593733 0.000692
SAA1 Serum amyloid A-1 protein − 2.366367299 0.014601
BCAN Brevican core protein − 2.239288875 0.001523
HIST3H2A Histone H2A type 3 − 2.206995388 0.00026
H2AFZ Histone H2A.z − 2.040764986 0.000545
NPPB N-terminal pro-BNP − 1.801131878 0.022043
PRSS2 Trypsin-2 − 1.678546737 0.033673
IGHE Immunoglobulin E − 1.639149251 0.026242
CHI3L1 Chitinase-3-like protein 1 − 1.550724228 0.035989
REG1A Lithostathine-1-alpha − 1.524188965 0.001408
PLA2G2A Phospholipase A2; membrane associated − 1.519910158 0.037611
IGFBP2 Insulin-like growth factor-binding protein 2 − 1.517034902 0.000329
EPO Erythropoietin − 1.307917165 0.02137
CKM Creatine kinase M-type − 1.262079547 0.040541
CD177 CD177 antigen − 1.261375377 0.013795
CTSD Cathepsin D − 1.247292872 0.000277
TIMP1 Metalloproteinase inhibitor 1 − 1.213901397 0.000257
ANGPT2 Angiopoietin-2 − 1.208573769 8.20E−05
ACY1 Aminoacylase-1 − 1.203247133 0.014948
THBS2 Thrombospondin-2 − 1.193185641 0.06772
RETN Resistin − 1.166268536 0.000407
LDHB L-lactate dehydrogenase B chain − 1.123231706 0.009274
CA3 Carbonic anhydrase 3 − 1.09182128 0.09789