Table 2 Top proteins downregulated in IPF plasma compared to healthy controls
Gene | Description | Log fold change | FDR |
|---|---|---|---|
GFAP | Glial fibrillary acidic protein | − 3.660959317 | 8.20E−05 |
IL1RL1 | Interleukin-1 receptor-like 1 | − 2.634896607 | 0.000167 |
BMPR1A | Bone morphogenetic protein receptor type-1A | − 2.467593733 | 0.000692 |
SAA1 | Serum amyloid A-1 protein | − 2.366367299 | 0.014601 |
BCAN | Brevican core protein | − 2.239288875 | 0.001523 |
HIST3H2A | Histone H2A type 3 | − 2.206995388 | 0.00026 |
H2AFZ | Histone H2A.z | − 2.040764986 | 0.000545 |
NPPB | N-terminal pro-BNP | − 1.801131878 | 0.022043 |
PRSS2 | Trypsin-2 | − 1.678546737 | 0.033673 |
IGHE | Immunoglobulin E | − 1.639149251 | 0.026242 |
CHI3L1 | Chitinase-3-like protein 1 | − 1.550724228 | 0.035989 |
REG1A | Lithostathine-1-alpha | − 1.524188965 | 0.001408 |
PLA2G2A | Phospholipase A2; membrane associated | − 1.519910158 | 0.037611 |
IGFBP2 | Insulin-like growth factor-binding protein 2 | − 1.517034902 | 0.000329 |
EPO | Erythropoietin | − 1.307917165 | 0.02137 |
CKM | Creatine kinase M-type | − 1.262079547 | 0.040541 |
CD177 | CD177 antigen | − 1.261375377 | 0.013795 |
CTSD | Cathepsin D | − 1.247292872 | 0.000277 |
TIMP1 | Metalloproteinase inhibitor 1 | − 1.213901397 | 0.000257 |
ANGPT2 | Angiopoietin-2 | − 1.208573769 | 8.20E−05 |
ACY1 | Aminoacylase-1 | − 1.203247133 | 0.014948 |
THBS2 | Thrombospondin-2 | − 1.193185641 | 0.06772 |
RETN | Resistin | − 1.166268536 | 0.000407 |
LDHB | L-lactate dehydrogenase B chain | − 1.123231706 | 0.009274 |
CA3 | Carbonic anhydrase 3 | − 1.09182128 | 0.09789 |