Table 1 Top proteins upregulated in IPF plasma compared to healthy controls
Gene | Description | Log fold change | FDR |
|---|---|---|---|
CCL28 | C-C motif chemokine 28 | 2.259556173 | 0.000231 |
CCL25 | C-C motif chemokine 25 | 2.073155182 | 0.000257 |
TLR4 | Toll-like receptor 4 | 1.856929692 | 0.00108 |
CCL11 | Eotaxin | 1.799567355 | 8.20E−05 |
RSPO3 | R-spondin-3 | 1.729221937 | 0.004217 |
UNC5D | Netrin receptor UNC5D | 1.689658186 | 0.000147 |
CCL17 | C-C motif chemokine 17 | 1.621455261 | 0.000257 |
TNFSF12 | Tumor necrosis factor ligand superfamily member 12 | 1.578591635 | 2.52E−06 |
FRZB | Secreted frizzled-related protein 3 | 1.506003793 | 0.001032 |
CCL21 | C-C motif chemokine 21 | 1.40240372 | 0.000945 |
CXCL9 | C-X-C motif chemokine 9 | 1.377906373 | 0.004835 |
GFRA1 | GDNF family receptor alpha-1 | 1.307361522 | 0.048836 |
MDK | Midkine | 1.272550426 | 0.035844 |
PRL | Prolactin | 1.271289238 | 8.20E−05 |
CCL4L1 | C-C motif chemokine 4-like | 1.25625883 | 0.054414 |
MAP2K4 | Dual specificity mitogen-activated protein kinase 4 | 1.218081304 | 0.006491 |
PDGFB | Platelet-derived growth factor subunit B | 1.17880283 | 0.026191 |
CCL5 | C-C motif chemokine 5 | 1.145110861 | 0.010668 |
AKT2 | RAC-beta serine/threonine-protein kinase | 1.126278423 | 0.000147 |
ICAM5 | Intercellular adhesion molecule 5 | 1.098941547 | 0.000257 |
CA6 | Carbonic anhydrase 6 | 1.094703466 | 0.061433 |
SPON1 | Spondin-1 | 1.061155009 | 0.025752 |
CXCL11 | C-X-C motif chemokine 11 | 1.059045713 | 0.056945 |
OLR1 | Oxidized low-density lipoprotein receptor 1 | 1.05710928 | 0.077666 |
CTSV | Cathepsin L2 | 1.026447098 | 0.000346 |