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Table 2 The association between dust exposure and spirometry in male workers using linear mixed-effects model (n = 6100)

From: Blood leukocyte count as a systemic inflammatory biomarker associated with a more rapid spirometric decline in a large cohort of iron and steel industry workers

Variable

FEV1 (ml/s)

FVC (ml)

FEV1/FVC (%)

Model 1

Model 2

Model 1

Model 2

Model 1

Model 2

β

SE

P

β

SE

P

β

SE

P

β

SE

P

β

SE

P

β

SE

P

Intercept

− 1263

172.2

 < 0.001

− 1400.4

103.1

 < 0.001

− 2269.7

178.7

 < 0.001

− 2100.1

114.8

 < 0.001

107.63

2.2

 < 0.001

17.33

1.5

 < 0.001

Age (yr)

− 22.85

1.6

 < 0.001

− 7.76

1.0

 < 0.001

− 21.38

1.7

 < 0.001

− 9.19

1.1

 < 0.001

− 0.10

0.02

 < 0.001

− 0.01

0.001

0.400

Current smoker

15.37

10.3

0.135

− 3.13

7.3

0.668

18.87

11.3

0.095

2.15

8.2

0.794

− 0.07

0.1

0.611

− 0.11

0.1

0.251

Packyears (py)

− 2.02

0.7

0.004

− 0.77

0.5

0.100

− 1.87

0.8

0.013

− 0.9

0.5

0.086

− 0.01

0.01

0.117

− 0.004

0.006

0.436

BMI (kg/m2)

− 10.52

1.5

 < 0.001

− 0.62

0.9

0.473

− 10.85

1.5

 < 0.001

− 2.88

1.0

0.003

− 0.02

0.01

0.233

0.03

0.01

0.002

Height (cm)

35.89

1.0

 < 0.001

13.95

0.6

 < 0.001

43.82

1.0

 < 0.001

19.74

0.7

 < 0.001

− 0.08

0.01

 < 0.001

− 0.04

0.007

 < 0.001

TIC (yr)

− 50.78

0.8

 < 0.001

199.38

5.6

 < 0.001

− 34.36

1.0

 < 0.001

259.77

6.5

 < 0.001

− 0.49

0.01

 < 0.001

5.98

0.2

 < 0.001

Spirometrybase (ml)

   

0.80

0.007

 < 0.001

   

0.77

0.007

 < 0.001

   

0.87

0.008

 < 0.001

Spirometrybase (ml) * TIC

   

− 0.06

0.001

 < 0.001

   

− 0.07

0.001

 < 0.001

   

− 0.07

0.002

 < 0.001

TWEI

− 21.76

7.3

0.003

− 22.04

5.4

 < 0.001

− 28.71

7.6

 < 0.001

− 20.53

6.1

 < 0.001

0.07

0.1

0.415

− 0.14

0.1

0.044

TWEI * TIC

   

2.00

1.0

0.052

   

3.78

1.2

0.002

   

− 0.03

0.01

0.031

Years of dust exposure (yr)

− 1.31

1.5

0.383

3.12

0.9

 < 0.001

− 2.22

1.6

0.155

4.27

1.0

 < 0.001

0.02

0.02

0.252

− 0.002

0.01

0.890

Years of dust exposure * TIC

   

− 1.43

0.1

 < 0.001

   

− 1.79

0.1

 < 0.001

  

− 0.002

0.001

0.044

 
  1. SE  standard error of mean, BMI  body mass index, TIC  time in cohort, FEV1  forced expiratory volume in 1 s, FVC  forced vital capacity, TWEI  time-weighted exposure intensity