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Fig. 6 | Respiratory Research

Fig. 6

From: Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis

Fig. 6

MiR-493-5p acted as a sensitizer of DDP and tumor inhibitor in DDP-resistant NSCLC cells by inducing ROCK1 downregulation. Transfection of miR-NC, miR-493-5p, miR-493-5p + pcDNA or miR-493-5p + ROCK1 was carried out in A549/DDP and H460/DDP cells. A, B ROCK1 expression was quantified using RT-qPCR and Western blot. C IC50 of DDP was measured via MTT assay. D–F cell proliferation and viability were detected via colony formation assay (D) and MTT (E–F). G–I cell cycle (G, H) and apoptosis (I) were analyzed by flow cytometry. J, K cell migration (J) and invasion (K) were evaluated using transwell assay. ***P < 0.001

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Respiratory Research

ISSN: 1465-993X

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