Table 3 SYRCLE risk of bias table
| Study ID | Cassin 1989 | Chen 2018 | Demir 2008 | Jouvencel 2003 | Kertesz 1992 | Park 2011 | Phillips 1995 | Schreiber 1985 | Schreiber 1987 | Xiao-Yan 2020 |
|---|---|---|---|---|---|---|---|---|---|---|
| 1. Selection bias- Sequence generation |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
| 2. Selection bias- Baseline characteristics |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
| 3. Selection bias- Allocation concealment |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
| 4. Performance bias- Random housing |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
Unclear risk The different groups were at least raised in the same room, but this does not report enough about the random housing |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
| 5. Performance bias- Blinding |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
|
6. Detection bias- Random outcome assessment |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Random outcome assessment for one outcome; unclear for others |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
| 7. Detection bias- Blinding |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
Unclear risk Tissues were prepared in a blinded fashion, although there is no information about blinding all the outcome assessors |
Low risk Quote: “All morphometric assessments were made blindly by the same observer (P.J.) (except for the bronchial alveolar attachments, by M.F.) on images of all lung sections” |
Unclear risk Not reported |
Unclear risk Not reported |
Unclear risk Not reported |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Not applicable There is no control group, i.e. all the animals got antileukotrienes |
Unclear risk Not reported |
| 8. Attrition bias- Incomplete outcome data |
Unclear risk Unclear if outcome data are reported for all animals |
Unclear risk Unclear if outcome data are reported for all animals |
Low risk All animals were included in the analysis |
Unclear risk Unclear if outcome data are reported for all animals |
Unclear risk Unclear if outcome data are reported for all animals |
Unclear risk Unclear if outcome data are reported for all animals |
Unclear risk Unclear if outcome data are reported for all animals |
Unclear risk Unclear if outcome data are reported for all animals |
Unclear risk Unclear if outcome data are reported for all animals |
High risk Quote "any loss of sample size due to deaths was made up for by random sampling" |
| 9. Reporting bias- Selective outcome reporting |
Unclear risk Protocol not available |
Unclear risk Protocol not available |
Unclear risk Protocol not available |
Unclear risk Protocol not available |
Unclear risk Protocol not available |
Unclear risk Protocol not available |
Unclear risk Protocol not available |
Unclear risk Protocol not available |
High risk Protocol not available; moreover, the study authors report that data for some outcomes are not shown |
Unclear risk Protocol not available |
| 10. Other- Other sources of bias |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |
Low risk None relevant |