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Table 3 SYRCLE risk of bias table

From: Antileukotrienes for the prevention and treatment of chronic lung disease in very preterm newborns: a systematic review

Study ID Cassin 1989 Chen 2018 Demir 2008 Jouvencel 2003 Kertesz 1992 Park 2011 Phillips 1995 Schreiber 1985 Schreiber 1987 Xiao-Yan 2020
1. Selection bias- Sequence generation Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
2. Selection bias- Baseline characteristics Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
3. Selection bias- Allocation concealment Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
4. Performance bias- Random housing Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
Unclear risk
The different groups were at least raised in the same room, but this does not report enough about the random housing
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
5. Performance bias- Blinding Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
6. Detection bias- Random outcome
assessment
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Random outcome assessment for one outcome; unclear for others
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
7. Detection bias- Blinding Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
Unclear risk
Tissues were prepared in a blinded fashion, although there is no information about blinding all the outcome assessors
Low risk
Quote: “All morphometric assessments were made blindly by the same observer (P.J.) (except for the bronchial alveolar attachments, by M.F.) on images of all lung sections”
Unclear risk
Not reported
Unclear risk
Not reported
Unclear risk
Not reported
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Not applicable
There is no control group, i.e. all the animals got antileukotrienes
Unclear risk
Not reported
8. Attrition bias- Incomplete outcome data Unclear risk
Unclear if outcome data are reported for all animals
Unclear risk
Unclear if outcome data are reported for all animals
Low risk
All animals were included in the analysis
Unclear risk
Unclear if outcome data are reported for all animals
Unclear risk
Unclear if outcome data are reported for all animals
Unclear risk
Unclear if outcome data are reported for all animals
Unclear risk
Unclear if outcome data are reported for all animals
Unclear risk
Unclear if outcome data are reported for all animals
Unclear risk
Unclear if outcome data are reported for all animals
High risk
Quote "any loss of sample size due to deaths was made up for by random sampling"
9. Reporting bias- Selective outcome reporting Unclear risk
Protocol not available
Unclear risk
Protocol not available
Unclear risk
Protocol not available
Unclear risk
Protocol not available
Unclear risk
Protocol not available
Unclear risk
Protocol not available
Unclear risk
Protocol not available
Unclear risk
Protocol not available
High risk
Protocol not available; moreover, the study authors report that data for some outcomes are not shown
Unclear risk
Protocol not available
10. Other- Other sources of bias Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
Low risk
None relevant
  1. Legend of the colours in the table: green = low risk of bias, orange = unclear, red = high; grey = not applicable