Table 3 Multivariable Cox regression models for year all-cause mortality among ECMO survivors
From: Chronic respiratory disease and survival outcomes after extracorporeal membrane oxygenation
Variable | Multivariable model | P-value |
|---|---|---|
HR (95% CI) | ||
Multivariable model 1 | ||
Post-ECMO CRD (vs control) | 1.47 (1.17, 1.86) | 0.001 |
Multivariable model 2 | ||
Post-ECMO CRD | ||
Post-ECMO COPD | 1.19 (0.80, 1.79) | 0.391 |
Post-ECMO Asthma | 1.54 (1.13, 2.11) | 0.007 |
Post-ECMO ILD | 2.33 (1.05, 6.40) | 0.042 |
Post-ECMO Lung cancer | 2.21 (0.81, 6.03) | 0.123 |
Post-ECMO Lung disease due to external agent | 1.07 (0.65, 1.77) | 0.787 |
Post-ECMO OSA | 3.60 (0.48, 27.08) | 0.214 |
Post-ECMO TB | 1.29 (0.67, 2.49) | 0.443 |
Other variables in model 1 | ||
Age, year | 1.04 (1.04, 1.05) | < 0.001 |
Sex, male (vs female) | 1.18 (0.98, 1.41) | 0.087 |
Residence at ECMO treatment | ||
Capital city (Seoul) | 1 | |
Other metropolitan city | 0.85 (0.65, 1.12) | 0.250 |
Other area | 0.95 (0.77, 1.17) | 0.633 |
Year of ECMO treatment | ||
2006 | 1 | |
2007 | 0.70 (0.41, 1.18) | 0.176 |
2008 | 0.50 (0.30, 0.86) | 0.012 |
2009 | 0.55 (0.33, 0.92) | 0.022 |
2010 | 0.82 (0.52, 1.30) | 0.406 |
2011 | 0.78 (0.50, 1.21) | 0.266 |
2012 | 0.78 (0.51, 1.20) | 0.264 |
2013 | 0.56 (0.37, 0.87) | 0.009 |
2014 | 0.63 (0.42, 0.96) | 0.030 |
Annual income level at ECMO treatment | ||
Q1 (Lowest) | 1 | |
Q2 | 0.94 (0.72, 1.21) | 0.615 |
Q3 | 0.67 (0.52, 0.86) | 0.001 |
Q4 (Highest) | 0.84 (0.67, 1.056) | 0.120 |
Annual case volume of ECMO therapy | ||
Q1 < 19 | 1 | |
Q2: 19–43 Q3: 44–102 | 0.76 (0.58, 0.99) | 0.039 |
1.11 (0.88., 1.41) | 0.379 | |
Q4 > 102 | 0.91 (0.69, 1.21) | 0.525 |
Charlson comorbidity index, point | 1.05 (1.02, 1.09) | 0.006 |
Pre-ECMO CRD (vs control) | 1.25 (1.04, 1.49) | 0.019 |
Underlying disability | ||
Mild to moderate | 0.86 (0.67, 1.11) | 0.251 |
Severe | 1.92 (1.53, 2.41) | < 0.001 |
Length of hospital stay, day | 1.00 (0.99, 1.01) | 0.795 |
Duration of ECMO therapy, day | 1.03 (1.02, 1.03) | < 0.001 |
Main diagnosis at ECMO treatment | ||
Cardiovascular group | 1 | |
Respiratory group | 1.34 (0.97, 1.85) | 0.076 |
Others | 2.19 (1.78, 2.68) | < 0.001 |