Table 1 Results of Mendelian randomisation (MR) analyses of FEV1/FVC on LVEDV
Instrument variables (IV) | MR method | SNPs | Odds ratio | 95% confidence interval | Estimate | Standard error | P-value | ||
|---|---|---|---|---|---|---|---|---|---|
Lower | Upper | ||||||||
Full (primary IV) | MR-IVW | 253 | 1.05 | 1.01 | 1.09 | 0.05 | 0.02 | 0.017 | |
MR-WM | 253 | 1.06 | 1.01 | 1.12 | 0.06 | 0.03 | 0.026 | ||
MR-Egger | 253 | 1.20 | 1.09 | 1.31 | 0.18 | 0.05 |  < 0.001 | ||
MR-PRESSO | 250 | 1.05 | 1.02 | 1.10 | 0.05 | 0.02 | 0.007 | ||
Subset | No association to potential covariates | MR-IVW | 146 | 1.07 | 1.01 | 1.13 | 0.06 | 0.03 | 0.019 |
MR-WM | 146 | 1.05 | 0.98 | 1.14 | 0.05 | 0.04 | 0.185 | ||
MR-Egger | 146 | 1.19 | 1.01 | 1.40 | 0.18 | 0.08 | 0.038 | ||
Association with FEV1/FVC in the SpiroMeta consortium population | MR-IVW | 73 | 1.06 | 1.00 | 1.12 | 0.06 | 0.03 | 0.043 | |
MR-WM | 73 | 1.05 | 0.97 | 1.13 | 0.05 | 0.04 | 0.214 | ||
MR-Egger | 73 | 1.12 | 0.98 | 1.28 | 0.12 | 0.07 | 0.091 | ||
MR-PRESSO | 72 | 1.06 | 1.01 | 1.12 | 0.06 | 0.03 | 0.021 | ||