Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Papakonstantinou, Eleni; Koletsa, Triantafyllia; Zhou, Liang; Fang, Lei; Roth, Michael; Karakioulaki, Meropi; Savic, Spasenija; Grize, Leticia; Tamm, Michael; Stolz, Daiana

doi:10.1186/s12931-021-01774-0

Table 4 Expression of glucocorticoid receptor in endobronchial biopsies from patients with different asthma endotypes/phenotypes before and after bronchial thermoplasty

From: Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Asthma endotypes-phenotypes	Expression of GR	Epithelial cells			Sub-epithelial mesenchymal cells			Nuclei of all cells
Asthma endotypes-phenotypes	Expression of GR	Before BT	After BT	P value*	Before BT	After BT	P value*	Before BT	After BT	P value*
eos ≥ 300/μL (N = 7)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	3 (42.9) 3 (42.9) 1 (14.3)	0 6 (66.7) 1 (14.3)	0.205	4 (57.1) 2 (28.6) 1 (14.3)	1 (14.3) 5 (71.4) 1 (14.3)	0.222	5 (71.4) 2 (28.6) 0	4 (57.1) 2 (28.6) 1 (14.3)	0.497
eos < 300/μL (N = 19)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	2 (27.8) 15 (55.5) 2 (16.7)	0 12 (68.4) 7 (31.6)	0.044	6 (44.4) 13 (50.0) 0	1 (5.3) 18 (94.7) 0	0.071	7 (44.4) 12 (55.5) 0	2 (10.5) 15 (78.9) 2 (10.5)	0.044
Atopy (N = 16)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	4 (25.0) 10 (62.5) 2 (12.5)	0 12 (75.0) 4 (25.0)	0.083	8 (50.0) 7 (43.7) 1 (6.3)	2 (12.5) 13 (81.2) 1 (6.3)	0.059	8 (50.0) 8 (50.0) 0	4 (25.0) 10 (62.5) 2 (12.5)	0.097
No Atopy (N = 10)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	1 (10.0) 8 (80.0) 1 (10.0)	0 7 (70.0) 3 (30.0)	0.124	2 (20.0) 8 (80.0) 0	0 10 (100.0) 0	0.975	4 (40.0) 6 (60.0) 0	2 (20.0) 7 (70.0) 1 (10.0)	0.253
Allergy (N = 14)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	4 (23.1) 8 (61.5) 2 (15.4)	0 11(76.9) 3 (23.1)	0.124	6 (38.5) 7 (53.8) 1 (7.7)	2 (15.4) 11 (76.9) 1 (7.7)	0.169	7 (46.1) 7 (53.9) 0	5 (38.5) 7 (46.1) 2 (15.4)	0.284
No allergy (N = 12)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	1 (8.3) 10 (83.3) 1 (8.3)	0 7 (68.4) 5 (31.6)	0.078	4 (33.3) 8 (66.7) 0	0 12 (100.0) 0	0.977	5 (41.7) 7 (58.3) 0	1 (8.3) 10 (83.3) 1 (8.3)	0.078
Smoke exposure (N = 9)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	0 9 (100.0) 0	0 6 (66.7) 3 (33.3)	0.970	3 (33.3) 6 (66.7) 0	1 (11.1) 7 (77.8) 1 (11.1)	0.206	5 (55.6) 4 (44.4) 0	2 (22.2) 6 (66.7) 1 (11.1)	0.140
No smoke exposure (N = 17)	Absence, n (%) Mild-Moderate, n (%) High, n (%)	5 (29.4) 9 (52.9) 3 (17.6)	0 12 (70.6) 5 (29.4)	0.073	7 (41.2) 9 (52.9) 1 (5.9)	1 (5.9) 16 (94.1) 0	0.072	7 (41.2) 10 (58.8) 0	4 (23.5) 11 (64.7) 2 (11.8)	0.162

*Comparisons between the groups were performed using a multinomial logistic regression model
BT bronchial thermoplasty, GR glucocorticoid receptor

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