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Table 4 Expression of glucocorticoid receptor in endobronchial biopsies from patients with different asthma endotypes/phenotypes before and after bronchial thermoplasty

From: Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Asthma endotypes-phenotypes Expression of GR Epithelial cells Sub-epithelial mesenchymal cells Nuclei of all cells
Before BT After BT P value* Before BT After BT P value* Before BT After BT P value*
eos ≥ 300/μL (N = 7) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
3 (42.9)
3 (42.9)
1 (14.3)
0
6 (66.7)
1 (14.3)
0.205 4 (57.1)
2 (28.6)
1 (14.3)
1 (14.3)
5 (71.4)
1 (14.3)
0.222 5 (71.4)
2 (28.6)
0
4 (57.1)
2 (28.6)
1 (14.3)
0.497
eos < 300/μL (N = 19) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
2 (27.8)
15 (55.5)
2 (16.7)
0
12 (68.4)
7 (31.6)
0.044 6 (44.4)
13 (50.0)
0
1 (5.3)
18 (94.7)
0
0.071 7 (44.4)
12 (55.5)
0
2 (10.5)
15 (78.9)
2 (10.5)
0.044
Atopy (N = 16) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
4 (25.0)
10 (62.5)
2 (12.5)
0
12 (75.0)
4 (25.0)
0.083 8 (50.0)
7 (43.7)
1 (6.3)
2 (12.5)
13 (81.2)
1 (6.3)
0.059 8 (50.0)
8 (50.0)
0
4 (25.0)
10 (62.5)
2 (12.5)
0.097
No Atopy (N = 10) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
1 (10.0)
8 (80.0)
1 (10.0)
0
7 (70.0)
3 (30.0)
0.124 2 (20.0)
8 (80.0)
0
0
10 (100.0)
0
0.975 4 (40.0)
6 (60.0)
0
2 (20.0)
7 (70.0)
1 (10.0)
0.253
Allergy (N = 14) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
4 (23.1)
8 (61.5)
2 (15.4)
0
11(76.9)
3 (23.1)
0.124 6 (38.5)
7 (53.8)
1 (7.7)
2 (15.4)
11 (76.9)
1 (7.7)
0.169 7 (46.1)
7 (53.9)
0
5 (38.5)
7 (46.1)
2 (15.4)
0.284
No allergy (N = 12) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
1 (8.3)
10 (83.3)
1 (8.3)
0
7 (68.4)
5 (31.6)
0.078 4 (33.3)
8 (66.7)
0
0
12 (100.0)
0
0.977 5 (41.7)
7 (58.3)
0
1 (8.3)
10 (83.3)
1 (8.3)
0.078
Smoke exposure (N = 9) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
0
9 (100.0)
0
0
6 (66.7)
3 (33.3)
0.970 3 (33.3)
6 (66.7)
0
1 (11.1)
7 (77.8)
1 (11.1)
0.206 5 (55.6)
4 (44.4)
0
2 (22.2)
6 (66.7)
1 (11.1)
0.140
No smoke exposure (N = 17) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
5 (29.4)
9 (52.9)
3 (17.6)
0
12 (70.6)
5 (29.4)
0.073 7 (41.2)
9 (52.9)
1 (5.9)
1 (5.9)
16 (94.1)
0
0.072 7 (41.2)
10 (58.8)
0
4 (23.5)
11 (64.7)
2 (11.8)
0.162
  1. *Comparisons between the groups were performed using a multinomial logistic regression model
  2. BT bronchial thermoplasty, GR glucocorticoid receptor