Table 3 Risk factors for AE in patients with fibrotic HP
From: Acute exacerbation of fibrotic hypersensitivity pneumonitis: incidence and outcomes
Characteristics | Unadjusted model | Multivariable model | ||
|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Age | 1.038 (0.988–1.091) | 0.139 | ||
Female sex | 1.303 (0.514–3.306) | 0.577 | ||
BMI | 0.919 (0.810–1.042) | 0.188 | ||
Ever smoker | 1.001 (0.386–2.591) | 0.999 | ||
Positive history of exposure to antigen | 1.239 (0.355–4.317) | 0.737 | ||
Pulmonary function test | ||||
FVC | 0.987 (0.955–1.007) | 0.151 | ||
DLCO | 0.959 (0.934–0.985) | 0.002 | 0.960 (0.935 – 0.985) | 0.002 |
TLC | 0.980 (0.944–1.017) | 0.291 | ||
BALF analysis | ||||
Neutrophil count | 0.984 (0.909–1.065) | 0.689 | ||
Lymphocyte count | 0.970 (0.937–1.003) | 0.072 | ||
UIP-like pattern on HRCT | 5.481 (1.566–19.182) | 0.008 | 4.013 (1.128 – 14.283) | 0.032 |