Association of endothelial activation assessed through endothelin-I precursor peptide measurement with mortality in COVID-19 patients: an observational analysis

Table 3 Logistic regression analyses forAssociation of initial proET-1 values and 30-day mortality in the different respiratory infections

	Pneumonia (n = 876)	Acute or chronic exacerbated bronchitis (n = 371)	SARS-CoV-2 (n = 74)
Regression analysis, OR^c (95% CI), p-value
Unadjusted model	51.1 (15.0 to 174.2), p < 0.01	215.3 (10.9 to 4246.2), p < 0.01	32.2 (2.3 to 455.5), p = 0.01
Multivariable model 1^a	36.7 (9.7 to 138.4), p < 0.01	82.0 (2.8 to 2394.0), p = 0.01	6.6 (0.2 to 193.3), p = 0.27
Multivariable model 2^b	25.4 (5.1 to 127.4), p < 0.01	120.7 (1.9 to 7499.7), p = 0.02	0.1 (0.0009 to 14.7), p = 0.38
Discrimination statistics AUC (95% CI)
AUC (95% CI) Unadjusted model	0.75 (0.67 to 0.83)	0.85 (0.75 to 0.95)	0.73 (0.58 to 0.89)

AUC, area under the curve; CI, confidence interval; OR, odd ratio; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2;
^aAdjusted for age and gender
^bAdjusted for age, gender, creatinine level, diastolic blood pressure as well as cancer and coronary artery disease
^cOdds ratio for 1 pmol/L increase of proET-1

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