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Fig. 4 | Respiratory Research

Fig. 4

From: Osimertinib alone as second-line treatment for brain metastases (BM) control may be more limited than for non-BM in advanced NSCLC patients with an acquired EGFR T790M mutation

Fig. 4

Survival analysis of BM. a The patients repeatedly developed BM after acquiring osimertinib resistance had shorter PFS and OS than patients without BM development after acquiring osimertinib resistance; b The patients that repeatedly developed BM after acquiring osimertinib resistance had shorter PFS and OS than patients without BM development after acquiring osimertinib resistance; c In patients without BM development after obtaining first-generation EGFR-TKI resistance and initial BM developed after acquiring osimertinib resistance, the PFS of the patients with BM developed after acquiring osimertinib resistance was shorter than that without BM development; d The patients with initial BM developed after acquiring osimertinib resistance did not show significant OS advantage over the patients without BM development. e Of the patients that developed BM after osimertinib group, patients with initial BM developed after obtaining first-generation EGFR-TKI resistance had shorter PFS than those without BM development; f In the patients without BM development after osimertinib group, the patients without BM development after obtaining first-generation EGFR-TKI resistance failed to show superior PFS than those with BM developed

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Respiratory Research

ISSN: 1465-993X

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