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Table 5 Allergenic sensitization (SPT positivity or Specific IgE) and blood eosinophilic count

From: FASE-CPHG Study: identification of asthma phenotypes in the French Severe Asthma Study using cluster analysis

 

Cluster 1

Early onset atopic

(N = 690)

Cluster 2

Obese

(N = 153)

Cluster 3

Late-onset

(N = 299)

Cluster 4

Eosinophilic

(N = 143)

Cluster 5

Aspirin-sensitivity

(N = 139)

Patients with allergic tests

N = 1158

p

Allergic sensitization

Yes

547 (91%)

81 (65.9%)

33 (16.9%)

67 (56.8%)

83 (68.6%)

811 (70%)

 < 0.0001

House dust mite

Yes

432 (71.9%)

66 (53.7%)

17 (8.7%)

49 (41.5%)

66 (54.5%)

630 (54.4%)

 < 0.0001

Pollens

Yes

317 (52.7%)

50 (40.7%)

13 (6.7%)

31 (26.3%)

52 (43%)

463 (40%)

 < 0.0001

Pets

Yes

252 (41.9%)

34 (27.6%)

7 (3.6%)

25 (21.2%)

41 (33.9%)

359 (31%)

 < 0.0001

Molds

Yes

98 (16.3%)

14 (11.4%)

7 (3.6%)

21 (17.8%)

19 (15.7%)

159(13.7%)

 < 0.001

Cockroaches

Yes

37 (6.2%)

6 (4.9%)

2 (1%)

6 (5.1%)

4 (3.3%)

55 (4.7%)

0.06

Blood eosinophil count

(n = 1075)

Means (Sd)

376.7 (± 354.2)

456.6 (± 613.9)

407.4 (± 425.5)

706.9 (± 691)

447.6 (± 399.4)

436 (± 465.6)

 < 0.0001

Min–Max

0–3700

0–3940

0–2340

0–5000

0–2200

0–5000

 < 0.0001

Distribution of blood eosinophil count

 < 150

112 (22.1%)

23 (18.7%)

66 (30.8%)

12 (10.1%)

23 (20.4%)

236 (22%)

 < 0.0001

 

[150–300]

142 (28.1%)

33 (26.8%)

48 (22.4%)

16 (13.4%)

28 (24.8%)

267 (24.8%)

 
 

[300–500]

133 (26.3%)

35 (28.5%)

36 (16.8%)

26 (21.8%)

21 (18.6%)

251 (23.3%)

 
 

[500–1000]

94 (18.6%)

23 (18.7%)

46 (21.5%)

39 (32.8%)

32 (28.3%)

234 (21.8%)

 
 

[1000–1500]

18 (3.6%)

2 (1.6%)

11 (5.1%)

20 (16.8%)

4 (3.5%)

55 (5.1%)

 
 

 >  = 1500

7 (1.4%)

7 (5.7%)

7 (3.3%)

6 (5%)

5 (4.4%)