Table 1 Clinical characteristics of FASE-CPHG severe asthma clusters
Cluster 1 Early onset atopic (N = 690) | Cluster 2 Obese (N = 153) | Cluster 3 Late-onset (N = 299) | Cluster 4 Eosinophilic (N = 143) | Cluster 5 Aspirin-sensitivity (N = 139) | Patients N = 1424 | p | ||
|---|---|---|---|---|---|---|---|---|
Gender | Male | 229 (33.2%) | 81 (52.9%) | 112 (37.5%) | 69 (48.3%) | 40 (28.8%) | 531 (37.3%) | < 0.0001 |
Female | 461 (66.8%) | 72 (47.1%) | 187 (62.5%) | 74 (51.7%) | 99 (71.2%) | 893 (62.7%) | ||
BMI | < 21 kg/m2 | 23 (3.3%) | 1 (0.7%) | 10 (3.3%) | 4 (2.8%) | 6 (4.3%) | 44 (3.1%) | < 0.0001 |
21–25 kg/m2 | 278 (40.3%) | 12 (7.8%) | 101 (33.8%) | 59 (41.3%) | 44 (31.7%) | 494 (34.7%) | ||
25–29 kg/m2 | 198 (28.7%) | 43 (28.1%) | 119 (39.8%) | 48 (33.6%) | 57 (41%) | 465 (32.7%) | ||
Obese > 30 kg/m2 Median | 191 (27.7%) 26 | 97 (63.4%) 32.9 | 69 (23.1%) 26 | 32 (22.4%) 25.7 | 32 (23%) 26.3 | 421 (29.6%) 26.5 | ||
Age at baseline | [18–40] | 216 (31.3%) | 4 (2.6%) | 18 (6%) | 18 (12.6%) | 20 (14.4%) | 276 (19.4%) | < 0.0001 |
[40–60] | 307 (44.5%) | 62 (40.5%) | 87 (29.1%) | 59 (41.3%) | 56 (40.3%) | 571 (40.1%) | ||
60 years and more Median | 167 (24.2%) 50 | 87 (56.9%) 61 | 194 (64.9%) 65 | 66 (46.2%) 59 | 63 (45.3%) 57.5 | 577 (40.5%) 56 | ||
Age at onset of asthma | < 12 years | 359 (52%) | 33 (21.6%) | 28 (9.4%) | 32 (22.4%) | 35 (25.2%) | 487 (34.2%) | < 0.0001 |
[12–40] | 256 (37.1%) | 52 (34%) | 91 (30.4%) | 67 (46.9%) | 67 (48.2%) | 533 (37.4%) | ||
40 years and more Median | 75 (10.9%) 12 | 68 (44.4%) 36 | 180 (60.2%) 44 | 44 (30.8%) 30 | 37 (26.6%) 30 | 404 (28.4%) 24 | ||
Severe asthma attacks | Ever | 362 (52.5%) | 93 (60.8%) | 135 (45.2%) | 60 (42%) | 88 (63.3%) | 738 (51.8%) | < 0.001 |
FEV1, % pred | Means (± sd) | 73.2 (± 19.3) | 68 (± 21) | 68.2 (± 22.2) | 76.7 (± 20.2) | 75.7 (± 22) | < 0.0001 | |