Fig. 4

PCAT-1 knockdown reverses acquired resistance to gefitinib in vivo. a PCAT-1 knockdown enhanced gefitinib-induced growth inhibition in xenograft tumors b Tumor volume was measured every 5 days. c Tumor weight was measured after removal. qRT-PCR was used to detect p-AKT (d) and AKT (e) expression. f The tumor sections were examined using immunohistochemical staining with AKT or p-AKT antibodies. *, p < 0.05, **, p < 0.01