Fig. 3
From: Plasma markers in pulmonary hypertension subgroups correlate with patient survival
Inflammatory markers in plasma of PAH and CTEPH patients at diagnosis and 1-year follow up. a–c Paired plasma concentrations for interleukin IL-10 (a), TGFβ (b) and CXCL13 (c) measured by ELISA, for a subset of patients from the indicated WHO PH subgroups, at diagnosis and at 1-year follow-up, compared with HCs. Data are shown as symbols for individual patients or HCs. d Paired plasma cytokine measurements by ELISA for CXCL9 at diagnosis and at 1-year follow-up for CTEPH patients and Kaplan Meyer survival analyses, starting at 12 months follow up, for CXCL9-high/low subgroups of CTEPH patients at 1-year follow up. Data are shown as symbols for individual patients or HCs; horizontal bars represent mean values; connecting lines between baseline and 1 year follow up samples indicate paired same-patient samples. Statistical analysis was performed using a Wilcoxon signed-rank test for the ELISA measurements and for the survival analysis a log-rank (Mantel-Cox) test and a Gehan-Breslow-Wilcoxon test was performed. * = p < 0.05