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Fig. 5 | Respiratory Research

Fig. 5

From: Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma

Fig. 5

Pseudotime analysis of CD4 + T cells demonstrated a strong association with interferon signaling in severe asthma. a PHATE analysis for pseudotemporal reconstruction of CD4 + T cells. b Heatmap of transcripts correlated with pseudotime identified multiple interferon-stimulated genes correlated with the response to poly I:C. c Regulon analysis identified IRF1, STAT1, IRF7, STAT2, and IRF9 as the top five transcription factors positively correlated with pseudotime and critical regulators of positively correlated genes in response to poly I:C

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Respiratory Research

ISSN: 1465-993X

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