Fig. 4

Single-cell RNAseq of PBMCs stimulated with poly I:C. a Poly I:C stimulation led to a robust increase in the expression of STAT1 and multiple interferon-stimulated genes in SA. b Genes involved in antigen presentation, including HLA-DRA, IGKC, IGHM, and CD74 had a heterogeneous expression across cell types and between SA and HC. Similarly, genes involved in ubiquitination and unfolded protein response also demonstrated a heterogeneous response across cells and disease status