Frequency and functional translation of low muscle mass in overweight and obese patients with COPD

Machado, Felipe V. C.; Spruit, Martijn A.; Groenen, Miriam T. J.; Houben-Wilke, Sarah; van Melick, Paula P.; Hernandes, Nidia A.; Schols, Annemie M. W. J.; Pitta, Fabio; Wouters, Emiel F. M.; Franssen, Frits M. E.

doi:10.1186/s12931-021-01689-w

Respiratory Research

Table 2 Characteristics of COPD patients referred for pulmonary rehabilitation with normal and low ASMI, after stratification into BMI categories

From: Frequency and functional translation of low muscle mass in overweight and obese patients with COPD

BMI group	Normal weight (n=205)		Overweight (n=156)		Obese (n=103)
ASMI group	Normal (n=25)	Low (n=180)	Normal (n=62)	Low (n=94)	Normal (n=87)	Low (n=16)
Subjects, % males	28.0	54.4*	53.2	63.8	55.1	56.2
Age, years	62 ± 9	64 ± 9	65 ± 10	66 ± 9	64 ± 9	63 ± 7
BMI, kg m^-2	21.9 ± 1.9	21.9 ± 1.8	27.8 ± 1.5	27.0 ± 1.2#	33.5 ± 2.9	31.7 ± 2.1#
FFMI, kg m^-2	16.3 [15.3–18.0]	15.3 [14.2–17.0]†	18.5 [16.5–19.6]	17.1 [15.7–18.3]#	20.1 [18.4–21.4]	18.0 [15.6–19.2]#
FEV₁, l	1.34 [0.91–1.84]	0.98 [0.74–1.37]†	1.47 [0.96–2.01]	1.09 [0.77–1.57]†	1.49 [1.09–1.83	1.01 [0.66–1.60]†
FEV₁, %pred	53.2 [43.4–67.1]	37.8 [29.1–52.1]#	59.8 [41.9–74.4]	42.4 [30.9–59.4]#	57.0 [44.6–68.8]	41.3 [27.3–54.5]†
FEV₁/FVC, %	38.3 [32.1–43.3]	31.0 [25.4–40.8]#	43.4 [32.5–50.7]	32.6 [25.5–43.0]†	44.0 [36.6–52.7]	33.5 [28.1–41.3]†
TLCO, %pred	52.0 [41.5–69.7]	42.1 [33.4–50.0]†	52.0 [40.8–63.1]	47.0 [36.7–61.0]	57.1 [49.2–68.5]	42.0 [34.3–49.0]#
mMRC, % grade ≥ 2	56.0	83.8†	75.8	82.4	82.6	93.7
6MWD, m	523 ± 92	417 ± 123#	471 ± 110	391 ± 122#	426 ± 114	356 ± 97*
6MWD, %pred	81 ± 12	63 ± 18#	76 ± 15	64 ± 17#	71 ± 16	59 ± 15†
Wmax, W	84 [61–98]	55 [44–74]#	74 [58–100]	64 [46–78]†	74 [61–95]	54 [37–72]*
Wmax, %pred	69 [46–96]	45 [32–65]#	58 [48–84]	47 [37–64]#	58 [43–86]	45 [36–55]*
VO₂max, ml m^-1	1244 [880–1438]	888 [691–1034]#	1156 [900–1402]	1060 [873–1303]	1230 [995–1501]	958 [818–1147]*
VO₂max, %pred	75 [51–102]	52 [37–72]#	67 [53–88]	56 [46–76]†	67 [55–97]	55 [46–70]
CWRT, s	285 [219–491]	206 [154–298]†	255 [187–360]	214 [175–314]	258 [172–461]	230 [172–304]
Quadriceps PT, Nm	90 ± 23	81 ± 29	139 ± 35	144 ± 29	113 ± 42	93 ± 29
Quadriceps PT, %pred	72 ± 18	58 ± 15#	76 ± 16	65 ± 17#	79 ± 18	64 ± 13*
SGRQ Total score, pts	55 [38–68]	63 [49–75]	58 [46–70]	65 [52–74]	65 [52–75]	66 [61–79]
HADS Anxiety score, pts	9 [3–11]	6 [4–11]	6 [5–12]	7 [5–11]	7 [5–11]	11 [5–13]*
HADS Depression score, pts	7 [4–11]	6 [3–10]	7 [4–10]	8 [4–11]	8 [4–10]	6 [4–14]
ASMI, kg m^-2	6.39 ± 0.80	5.55 ± 0.79#	6.93 ± 0.86	6.07 ± 0.87#	7.53 ± 1.00	6.20 ± 0.76
Lumbar spine T-score	− 2.04 ± 1.60	− 1.05 ± 1.53†	− 0.88 ± 1.35	− 0.90 ± 1.67	− 0.74 ± 1.46	− 0.98 ± 1.41
Hip T-score	− 1.66 ± 0.99	− 1.75 ± 0.98	− 1.66 ± 0.89	− 1.70 ± 0.98	− 1.11 ± 1.03	− 1.41 ± 0.80

Mean ± standard deviation, median [interquartile range 25–75%] or frequency reported. ASMI appendicular skeletal muscle mass index, BMI body mass index, FFMI fat-free mass index, FEV₁ forced expiratory volume in the first second, FVC forced vital capacity, TLCO transfer factor for carbon monoxide, mMRC modified Medical Research Council, 6MWD six-minute walking distance, Wmax peak load during cycle ergometry, VO₂max peak oxygen uptake during cycle ergometry, CWRT time during constant work rate test, PT peak torque, SGRQ St George’s Respiratory Questionnaire, HADS hospital anxiety and depression questionnaire, *P < 0.05 versus normal FFMI from the same BMI group. †P < 0.01 versus normal FFMI from the same BMI group. #P < 0.001 versus normal FFMI from the same BMI group

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