From: Frequency and functional translation of low muscle mass in overweight and obese patients with COPD
BMI group | Normal weight (n=205) | Overweight (n=156) | Obese (n=103) | |||
---|---|---|---|---|---|---|
ASMI group | Normal (n=25) | Low (n=180) | Normal (n=62) | Low (n=94) | Normal (n=87) | Low (n=16) |
Subjects, % males | 28.0 | 54.4* | 53.2 | 63.8 | 55.1 | 56.2 |
Age, years | 62 ± 9 | 64 ± 9 | 65 ± 10 | 66 ± 9 | 64 ± 9 | 63 ± 7 |
BMI, kg m-2 | 21.9 ± 1.9 | 21.9 ± 1.8 | 27.8 ± 1.5 | 27.0 ± 1.2# | 33.5 ± 2.9 | 31.7 ± 2.1# |
FFMI, kg m-2 | 16.3 [15.3–18.0] | 15.3 [14.2–17.0]†| 18.5 [16.5–19.6] | 17.1 [15.7–18.3]# | 20.1 [18.4–21.4] | 18.0 [15.6–19.2]# |
FEV1, l | 1.34 [0.91–1.84] | 0.98 [0.74–1.37]†| 1.47 [0.96–2.01] | 1.09 [0.77–1.57]†| 1.49 [1.09–1.83 | 1.01 [0.66–1.60]†|
FEV1, %pred | 53.2 [43.4–67.1] | 37.8 [29.1–52.1]# | 59.8 [41.9–74.4] | 42.4 [30.9–59.4]# | 57.0 [44.6–68.8] | 41.3 [27.3–54.5]†|
FEV1/FVC, % | 38.3 [32.1–43.3] | 31.0 [25.4–40.8]# | 43.4 [32.5–50.7] | 32.6 [25.5–43.0]†| 44.0 [36.6–52.7] | 33.5 [28.1–41.3]†|
TLCO, %pred | 52.0 [41.5–69.7] | 42.1 [33.4–50.0]†| 52.0 [40.8–63.1] | 47.0 [36.7–61.0] | 57.1 [49.2–68.5] | 42.0 [34.3–49.0]# |
mMRC, % grade ≥ 2 | 56.0 | 83.8†| 75.8 | 82.4 | 82.6 | 93.7 |
6MWD, m | 523 ± 92 | 417 ± 123# | 471 ± 110 | 391 ± 122# | 426 ± 114 | 356 ± 97* |
6MWD, %pred | 81 ± 12 | 63 ± 18# | 76 ± 15 | 64 ± 17# | 71 ± 16 | 59 ± 15†|
Wmax, W | 84 [61–98] | 55 [44–74]# | 74 [58–100] | 64 [46–78]†| 74 [61–95] | 54 [37–72]* |
Wmax, %pred | 69 [46–96] | 45 [32–65]# | 58 [48–84] | 47 [37–64]# | 58 [43–86] | 45 [36–55]* |
VO2max, ml m-1 | 1244 [880–1438] | 888 [691–1034]# | 1156 [900–1402] | 1060 [873–1303] | 1230 [995–1501] | 958 [818–1147]* |
VO2max, %pred | 75 [51–102] | 52 [37–72]# | 67 [53–88] | 56 [46–76]†| 67 [55–97] | 55 [46–70] |
CWRT, s | 285 [219–491] | 206 [154–298]†| 255 [187–360] | 214 [175–314] | 258 [172–461] | 230 [172–304] |
Quadriceps PT, Nm | 90 ± 23 | 81 ± 29 | 139 ± 35 | 144 ± 29 | 113 ± 42 | 93 ± 29 |
Quadriceps PT, %pred | 72 ± 18 | 58 ± 15# | 76 ± 16 | 65 ± 17# | 79 ± 18 | 64 ± 13* |
SGRQ Total score, pts | 55 [38–68] | 63 [49–75] | 58 [46–70] | 65 [52–74] | 65 [52–75] | 66 [61–79] |
HADS Anxiety score, pts | 9 [3–11] | 6 [4–11] | 6 [5–12] | 7 [5–11] | 7 [5–11] | 11 [5–13]* |
HADS Depression score, pts | 7 [4–11] | 6 [3–10] | 7 [4–10] | 8 [4–11] | 8 [4–10] | 6 [4–14] |
ASMI, kg m-2 | 6.39 ± 0.80 | 5.55 ± 0.79# | 6.93 ± 0.86 | 6.07 ± 0.87# | 7.53 ± 1.00 | 6.20 ± 0.76 |
Lumbar spine T-score | − 2.04 ± 1.60 | − 1.05 ± 1.53†| − 0.88 ± 1.35 | − 0.90 ± 1.67 | − 0.74 ± 1.46 | − 0.98 ± 1.41 |
Hip T-score | − 1.66 ± 0.99 | − 1.75 ± 0.98 | − 1.66 ± 0.89 | − 1.70 ± 0.98 | − 1.11 ± 1.03 | − 1.41 ± 0.80 |