Fig. 2
From: Enhanced lung inflammatory response in whole-body compared to nose-only cigarette smoke-exposed mice
Lung remodeling in air and CS-exposed mice. a H&E staining of lung sections (× 200) from a representative control and CS-exposed mouse of the nose-only and whole-body system. Semi-quantitative score of b epithelial damage (thin arrow) and c mucus production (thick arrow). Pre- and post-elastin degradation markers were determined via d the MMP12/TIMP1 mRNA expression ratio and e total serum desmosine (*p < 0.05; nose-only vs whole-body) and iso-desmosine ($p < 0.05; control vs whole-body). f Airspace enlargement (Linear mean intercept, Lm) was measured with an in-house program. *p < 0.05; **p < 0.01; ***p < 0.001. Data are expressed as median and IQR (n = 8–15)