Fig. 7
From: Olodaterol exerts anti-inflammatory effects on COPD airway epithelial cells
The effect of the β2AR antagonists ICI 118,551 and butaxamine on olodaterol inhibition of IL-8 secretion. NCI-H292 cells were treated with 2 µg/mL LPS with and without 0.01 µM olodaterol. To antagonize β2AR, cells were pre-treated with 30 nM of ICI 118,551 or 100 nM of butaxamine for 1 h, followed by addition of 0.01 µM olodaterol for 8 h and 2 µg/mL LPS overnight for a total of 24 h. a Olodaterol significantly inhibited LPS-mediated IL-8 secretion (**p < 0.01) but not in the presence of 30 nM of ICI 118,551. b Olodaterol also inhibited LPS-mediated IL-8 secretion (*p < 0.05) but not in the presence of 100 nM of butaxamine. n = 6. Data was analyzed via one-way ANOVA with Bonferroni correction