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Table 2 Observed rate of FEV1 decline according to GOLD subgroups, gender, smoking status and BMI category

From: Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis

 

GOLD Grades 1 and 2

 
 

Male

(N = 5457)

Female

(N = 3229)

p-value*

Rate of FEV1 decline, mean (95% CI), mL/year

− 36.6

(− 37.6, − 35.6)

− 29.2

(− 30.2, − 28.1)

p < 0.001

Age, y, mean (SD)

51.8 (8.8)

51.9 (9.3)

p = 0.40

BMI, kg/m2, mean(SD)

26.3 (3.9)

24.8 (4.7)

p < 0.001

BMI category, n (%)

  

p < 0.001

 Underweight (BMI < 18.5)

54 (1.0)

109 (3.4)

 

 Normal (BMI 18.5–25.0)

2082 (38.2)

1,863 (57.7)

 Overweight (BMI 25.1–30.0)

2477 (45.4)

863 (26.7)

 Obese (BMI > 30.1)

844 (15.5)

394 (12.2)

Smoking status, n (%)

  

p = 0.02

 Ex-smoker

1472 (45.7)

2350 (43.1)

 

 Current smoker

1750 (54.3)

3099 (56.9)

  1. BMI body mass index, GOLD Global Initiative for Chronic Obstructive Lung Disease (GOLD) spirometric grades, N number, SD standard deviation
  2. *p-values were obtained from Kruskal–Wallis test for continuous variables and Pearson chi-square test for categorical variables