Fig. 4
From: Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung
The mitochondrial unfolded protein response is increased in HPS-2 alveolar epithelial cells. a Transcript levels for activating transcription factor 4, 5 and C/EBP Homologous Protein in control and HPS-2-MLE15 cells (n = 4, each group). b, c Transcript levels for heat shock protein (HSP) 10 and HSP70, serine protease Htra2, the mitochondrial proteases yeast mitochondrial AAA metalloprotease (Yme1el), caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit (CLPP) and long protease 1 (Lonp1) and Sirtuin 3 (Sirt3) in control and HPS-2-MLE15 cells (n = 4–5, each group). d Western blot for CLPP, HtrA2 and SIRT3 in control and HPS2-MLE15 cells (n = 3–6, each group). Beta actin was used as a loading control. Densitometry measurements are shown together. Student’s t-test. *P < 0.05, **P < 0.01 vs. control group