Fig. 5
From: Bitter taste receptor agonists regulate epithelial two-pore potassium channels via cAMP signaling
Proposed Model for bitter taste receptor stimulation of Gα and Gβγ pathways in human respiratory epithelium. Denatonium stimulation of bitter taste receptors on SCCs activates both calcium and cAMP as downstream signaling molecules that can induce epithelial defensin release. cAMP-mediated closure of apical potassium channels may reduce the threshold for calcium-mediated defensin release