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Table 1 Patients’ characteristics at baseline and last follow-up

From: Risk assessment in precapillary pulmonary hypertension: a comparative analysis

 

Baseline (N = 130)

Mean ± SD

Last follow-up (N = 87)

Mean ± SD

p-value

Baseline to 2018

Age years

62 ± 15

67 ± 15

 

Female no. (%)

78 (60)

55 (63)

 

BMI kg/m

27 ± 6

26 ± 6

0.004

WHOFc I/II/III/IV no. (%)

5/43/70/12 (4/33/54/9)

21/30/33/3 (24/35/38/3)

< 0.001

SMWD m

321 ± 132

358 ± 143

0.005

Blood and serum parameters

   

 NT-proBNP ng/L

2631 ± 8747

1904 ± 7580

0.001

 Haemoglobin g/L

140 ± 23

135 ± 26

0.962

 Transferrin saturation %

22 ± 14

26 ± 29

0.448

 Ferritin µg/L

126 ± 150

99 ± 89

0.106

 RDW %

14.9 ± 1.9

14.9 ± 2.4

0.527

 CRP mg/dL

0.9 ± 1.6

0.9 ± 1.8

0.959

 GFR mL/min/1.73 m2

78 ± 28

75 ± 28

< 0.001

 Creatinin mg/dL

1.1 ± 0.6

1.2 ± 1.1

0.003

Pulmonary function and BGA

 DLCO %

64 ± 23

65 ± 23

< 0.001

 KCO %

82 ± 27

81 ± 27

0.002

 paO2 mmHg

69 ± 14

67 ± 13

< 0.001

 SO2%

93 ± 5

93 ± 5

0.001

Echocardiography

   

 RAA cm2

22 ± 5

18 ± 7

< 0.001

 TAPSE mm

18 ± 4

23 ± 5

< 0.001

 sPAP mmHg

61 ± 21

48 ± 21

< 0.001

 Pericardial eff. no.(%)

21 (16)

5 (6)

0.038

  1. Data are represented as mean ± 1 standard deviation (SD); N depicts the number of valid data for retrospective analysis. p-values depict Wilcoxon, Friedman (continuous variables) or Pearson Chi-Square (ordinal or dichotomous variables) test results for time-dependent changes during the observation period
  2. BMI: body mass index, WHOFc: World Health Organization functional class, SMWD: six-minute walking distance, NT-pro BNP: N-terminal of the pro-hormone brain natriuretic peptide, RDW: red blood cell distribution width, CRP: C reactive protein, GFR: glomerular filtration rate, RAA: right atrial area, TAPSE: tricuspid annular plane systolic excursion, sPAP: systolic pulmonary arterial pressure, pericardial eff.: pericardial effusion; BGA, blood gas analysis; DLCO: diffusing capacity for carbon monoxide, depicted as percentage of normal, KCO: carbon monoxide transfer coefficient, also known as Krogh-Index (DLCO/VA), depicted as percentage of normal, paO2: arterial partial pressure of oxygen, SO2: oxygen saturation
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Respiratory Research

ISSN: 1465-993X

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