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Table 2 Capillaroscopic abnormalities in patients with idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

From: Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study

  IPAH CTEPH Healthy controls P-value*
N 14 14 30  
Avascular areas (n/mm) 0.75 ± 0.26+ 0.67 ± 0.42# 0.15 ± 0.2+#  < 0.001
Avascular areas, n (%) 13 (92.8) 12 (85.7) 8 (26.6)  < 0.001
Capillary width (μm) 35.1 ± 5.1+ 39.2 ± 4.6# 29.5 ± 4.3+#  < 0.001
Arterial limb (μm) 10.2 ± 2.2+ 10.3 ± 1.5# 7.4 ± 1.3+#  < 0.001
Venous limb (μm) 12.4 ± 2.4+ 12.6 ± 2.4# 8.8 ± 1.4+#  < 0.001
Irregularly enlarged (loops/mm) 1.4 ± 1.2+ 1.2 ± 0.7# 0.4 ± 0.5+#  < 0.001
Capillary length (μm) 323.8 ± 84.9 315.2 ± 107.7 313.2 ± 83.9 0.99
Edema, n (%) 3 (21.4) 0 0
Microhemorrhages (n/mm) 0.25 (0.25) 0.12 (0.4) 0 (0)  < 0.001
Microhemorrhages, n (%) 8 (57.1) 5 (35.7) 0  < 0.001
Thrombosis (n/mm) 2.2 ± 0.8$ 3.2 ± 1.3$# 1.4 ± 0.8#  < 0.001
Disorganized capillaries (loops/mm) 0.5 ± 0.4 0.4 ± 0.3 0.2 ± 0.4 0.079
Shape abnormalities (loops/mm) 1.8 ± 1.0$ 3.1 ± 1.2$# 1.1 ± 0.8#  < 0.001
Ramified capillaries (loops/mm) 0.5 ± 0.4+ 0.7 ± 0.3# 0.2 ± 0.2+#  < 0.001
  1. Categorical variables are presented as frequency and percentage, n (%)
  2. Continuous variables are presented as mean value ± standard deviation or median value and interquartile range
  3. IPAH idiopathic pulmonary arterial hypertension, CTEPH chronic thromboembolic pulmonary hypertension
  4. *A p-value < 0.05 is considered statistically significant. Comparisons were made among the three groups
  5. +Statistical significance between IPAH and controls. P-value < 0.01
  6. #Statistical significance between CTEPH and controls. P-value < 0.01
  7. $Statistical significance between CTEPH and IPAH. P-value < 0.01