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Table 3 Univariate logistic analyses

From: Mask side-effects in long-term CPAP-patients impact adherence and sleepiness: the InterfaceVent real-life study

 

CPAP-non-adherence (< 4 h/day)

Residual Excessive Sleepiness (ESS ≥ 11)

Crude OR [95% CI]

P value

Crude OR [95% CI]

P value

Demographics

    

 Age (years)

0.98 [0.97; 1.00]

0.046

0.99 [0.97; 0.99]

0.02

 Gender, female

0.55 [0.34; 0.80]

0.002

1.10 [0.80; 1.50]

0.55

 BMI (kg/m2)

0.95 [0.92; 0.99]

0.012

0.99 [0.96; 1.01]

0.27

 Diagnostic AHI (events/h)

1.00 [1.00; 1.00]

0.25

0.99 [0.99; 1.00]

0.31

 Active smokers

1.40 [0.84; 2.36]

0.20

1.26 [0.84; 1.89]

0.27

 Beard

0.80 [0.40; 1.60]

0.31

1.34 [0.88; 2.04]

0.10

 Mustache

1.35 [0.66; 2.74]

0.27

0.80 [0.44; 1.46]

0.23

 Active workers

1.50 [0.98; 2.29]

0.059

1.36 [0.98; 1.89]

0.07

 Presence of bed partner

0.51 [0.35; 0.74]

< 0.001

0.93 [0.69; 1.27]

0.65

Epworth Scale

    

 ESS (0–24 scores)

1.00 [0.99; 1.00]

0.005

NA

NA

EQ-5D-3L

    

 Problems with mobility

1.18 [0.78; 1.78]

0.44

1.55 [1.14; 2.11]

0.005

 Problems with self-care

1.22 [0.60; 2.51]

0.58

1.50 [0.89; 2.56]

0.13

 Problems with usual activities

1.21 [0.78; 1.89]

0.39

2.06 [1.50; 2.83]

< 0.001

 Problems of pain/discomfort

1.10 [0.76; 1.60]

0.62

1.79 [1.33; 2.42]

0.001

 Problems of anxiety/depression

1.23 [0.84; 1.78]

0.29

2.42 [1.82; 3.21]

< 0.001

 EQ-5D-3L health VAS (0–100 score)

1.01 [0.97; 1.01]

0.071

0.99 [0.99; 1.00]

< 0.001

Device

    

 CPAP-usage (h/day)

NA

NA

0.99 [0.99; 1.00]

0.001

 Current AHIflow (events/h)

1.04 [0.99; 1.09]

0.054

0.99 [0.95; 1.04]

0.39

 Treatment duration (years)

0.93 [0.89; 0.97]

< 0.001

1.00 [0.98; 1.03]

0.93

 Fixed pressure

0.49 [0.24; 0.98]

0.043

0.67 [0.43; 1.07]

0.10

 Mean pressure (cmH2O)

0.92 [0.84; 1.00]

0.058

0.98 [0.92; 1.05]

0.68

 90th/95th pressure (cmH2O)

0.93 [0.85; 1.01]

0.072

1.02 [0.96; 1.09]

0.43

 Comfort mode

1.33 [0.84; 2.11]

0.22

0.90 [0.61; 1.32]

0.58

 Heated humidifier

1.45 [0.98; 2.12]

0.061

1.12 [0.84; 1.49]

0.43

 Heated breathing tube

1.71 [0.79; 3.68]

0.17

1.06 [0.53; 2.12]

0.87

Mask

    

 Nasal mask

Ref

0.003

Ref

0.46

 Oronasal mask

1.95 [1.29; 2.94]

0.0625

1.16 [0.84; 1.59]

0.81

 Nasal pillows mask

1.83 [1.13; 2.97]

0.23

1.23 [0.85; 1.79]

0.44

 Availability of the mask since 2013 (%)

2.49 [1.72; 3.61]

< 0.001

1.21 0.92; 1.60]

0.17

 Device reported leaks (0–100 score)

1.0 [0.99; 1.02]

0.23

1.00 [0.99; 1.00]

0.67

 Device reported leaks (median of the 95th percentile of unintentional leaks (l/min))

1.01 [0.99; 1.02]

0.34

0.99 [0.98; 1.01]

0.28

 Chin strap

1.00 [1.00;1.00]

0.98

3.92 [0.87; 17.6]

0.07

Side effects

    

 Dry mouth (0–10 VAS score)

1.05 [1.00; 1.11]

0.044

1.14 [1.09; 1.18]

< 0.001

 Partner disturbing leaks (0–10 VAS score)

0.89 [0.84; 0.95]

< 0.001

1.08 [1.05; 1.13]

< 0.001

 Patient reported leaks (0–10 VAS score)

1.00 [0.94; 1.06]

0.96

1.15 [1.10; 1.21]

< 0.001

 Red eyes (0–10 VAS score)

1.01 [0.94; 1.08]

0.86

1.10 [1.05; 1.15]

< 0.001

 Itchy eyes (0–10 VAS score)

0.99 [0.92; 1.07]

0.90

1.11 [1.05; 1.16]

< 0.001

 Noisy mask (0–10 VAS score)

0.99 [0.93; 1.07]

0.90

1.16 [1.10; 1.22]

< 0.001

 Dry nose (0–10 VAS score)

1.04 [0.99; 1.10]

0.14

1.15 [1.10; 1.20]

< 0.001

 Stuffed nose (0–10 VAS score)

1.01 [0.94; 1.08]

0.81

1.13 [1.09; 1.19]

< 0.001

 Runny nose (0–10 VAS score)

0.97 [0.90; 1.05]

0.44

1.06 [1.01; 1.12]

0.013

 Heavy mask (0–10 VAS score)

0.92 [0.81; 1.04]

0.18

1.20 [1.12; 1.28]

< 0.001

 Mask pain (0–10 VAS score)

1.05 [0.96; 1.15]

0.25

1.10 [1.03; 1.20]

0.003

 Mask injury (0–10 VAS score)

1.01 [0.91; 1.11]

0.90

1.11 [1.04; 1.18]

0.002

 Harness pain (0–10 VAS score)

1.07 [0.96; 1.18]

0.21

1.11 [1.03; 1.20]

0.006

 Harness injury (0–10 VAS score)

0.93 [0.79; 1.09]

0.36

1.12 [1.03; 1.21]

0.01

 Nose bleeding

0.53 [0.17; 1.73]

0.30

1.16 [0.60; 2.27]

0.66

 Aerophagia

1.45 [0.80; 2.61]

0.22

1.55 [0.99; 2.44]

0.056

 Number* [0/14]

1.01 [0.96; 1.05]

0.84

1.12 [1.08; 1.16]

< 0.001

  1. AHI: Apnea–Hypopnea Index, BMI: body mass index, CPAP: continuous positive airway pressure, ESS: Epworth Sleepiness Scale, OR: odds ratio; NA: not applicable, VAS: Visual Analogue Scale
  2. Italics variables are included in multivariable analyses
  3. * Number of side effects; dichotomous data created when the VAS scale for the side effect was above or equal to 1. This variable was not included in the multivariable analyses because of its collinearity with MRSE-variables