From: Telomere length dynamics over 10-years and related outcomes in patients with COPD
Variable | Short T/Sd N = 87 | Medium T/Sd N = 88 | Long T/Sd N = 88 | p-value |
---|---|---|---|---|
T/S ratioa | 0.40 ± 0.08 | 0.60 ± 0.05 | 0.92 ± 0.22 | < 0.001 |
TL (bp)a | 5248 ± 855 | 7346 ± 535 | 10,757 ± 2371 | < 0.001 |
Agea | 66 ± 9 | 64 ± 9 | 61 ± 10 | 0.005 |
Sex (male %) | 76 | 80 | 66 | 0.104 |
BMIa | 28 ± 6 | 28 ± 5 | 26 ± 5 | 0.068 |
Smoking habit (pack-year)a,c | 69 ± 30 | 65 ± 26 | 58 ± 24 | 0.023 |
Active smoking (%) | 43 | 43 | 40 | 0.888 |
FEV1 (L)a | 1.49 ± 0.64 | 1.60 ± 0.65 | 1.46 ± 0.66 | 0.326 |
FEV1 (% pred)a | 58 ± 21 | 59 ± 20 | 55 ± 23 | 0.544 |
FVC (% pred)a | 87 ± 21 | 90 ± 23 | 85 ± 23 | 0.348 |
FEV1/FVC (% pred)a | 52 ± 13 | 51 ± 11 | 51 ± 13 | 0.930 |
PaO2a | 71 ± 12 | 73 ± 11 | 71 ± 12 | 0.605 |
KCOa | 79 ± 27 | 77 ± 24 | 69 ± 26 | 0.059 |
ICTLC (%)a | 35 ± 8 | 35 ± 8 | 34 ± 10 | 0.875 |
6MWD (mts)a | 477 ± 94 | 486 ± 102 | 480 ± 105 | 0.824 |
mMRC dysneab | 1 (0–2) | 1 (0–2) | 1 (0–2) | 0.210 |
BODE indexb | 1 (0–2) | 1 (0–3) | 1 (0–3) | 0.223 |
Charlson indexb | 0 (0–1) | 0 (0–1) | 0 (0–1) | 0.769 |
Exacerbationsb | 0 (0–1) | 1 (0–2) | 0 (0–1) | 0.146 |