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Table 5 Univariate and multivariate analysis of the effects of ICS cessation compared to continuing triple therapy on secondary outcomes in the outcome year

From: Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

  Univariate analysis Multivariate analysis
  IRR 95% CI p-value IRR 95% CI p-value
Exacerbation rate
Managed in primary care 1.05 0.95 to 1.17 0.330 1.33 1.10 to 1.60 0.003
Resulting in A&E attendance 1.24 0.95 to 1.62 0.109 1.72 1.03 to 2.86 0.036
  ß coef 95% CI p-value ß coef 95% CI p-value
Change in FEV1 − 30.03 − 61.39 to 1.33 0.061 − 24.85 − 55.55 to 5.84 0.112
  OR 95% CI p-value OR 95% CI p-value
CAT score
 ≥ 10 0.97 0.67 to 1.43 0.884 1.02 0.60 to 1.76 0.936
mMRC dyspnea score
 ≥ 2 0.88 0.74 to 1.04 0.129 0.77 0.54 to 1.10 0.161