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Table 5 Required number of primary endpoint events

From: Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy – the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial

  HR = 0.50 HR = 0.55 HR = 0.60 HR = 0.65 HR = 0.70 HR = 0.75
80% power 65 88 120 169 247 379
85% power 75 100 138 194 282 434
90% power 87 118 161 226 330 508
  1. Calculations performed using nQuery 7.0 and assume a 0.05 type I error rate (two-sided) with 1:1 randomization