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Fig. 6 | Respiratory Research

Fig. 6

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 6

Effect of melatonin and ramelteon on lung pathology. a Hematoxylin and eosin staining analysis of lung pathological injury. Representative photomicrographs were taken at a magnification of × 400. b The numbers of neutrophils per high-power field (× 400 magnification), and c lung injury score. Histological evaluation of lung tissues showed that neutrophil infiltration and the lung injury score were increased in the VILI group. Melatonin or ramelteon treatment significantly attenuated these histopathological changes, but the protective effect of melatonin and ramelteon was abrogated by luzindole treatment. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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