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Fig. 4 | Respiratory Research

Fig. 4

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 4

Effect of melatonin and ramelteon on IL-10 levels in BALF and STAT3 expression in the lung tissue. The p-STAT 3 level in lung tissue was determined by western blotting. β-Actin served as a loading control for cytoplasmic proteins. VILI significantly decreased IL-10 levels in BALF (a) and increased p-STAT3 protein expression in the lung tissue (b). Melatonin or ramelteon treatment significantly reversed this phenomenon. When luzindole was added, the protective effect of melatonin and ramelteon was blocked. Data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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Respiratory Research

ISSN: 1465-993X

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