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Fig. 3 | Respiratory Research

Fig. 3

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 3

Effect of melatonin and ramelteon on TNF-α, IL-1β, IL-6, and CXCL-1 concentrations in BALF. TNF-α (a), IL-1β (b), IL-6 (C), and CXCL-1 (d) levels in BALF increased significantly in the VILI group. The increases in the BALF protein concentrations were significantly attenuated by treatment with melatonin or ramelteon. The protective effect of melatonin and ramelteon was abrogated by luzindole treatment. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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