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Fig. 10 | Respiratory Research

Fig. 10

From: Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production

Fig. 10

Effect of anti-IL-10 antibody on melatonin- and ramelteon-mediated VILI protection against lung edema. a Lung weight/body weight ratio. b W/D weight ratio. c Protein levels in BALF. Melatonin or ramelteon treatment significantly attenuated the increase in LW/BW and W/D weight ratios and protein levels in VILI. When an anti-IL-10 antibody was administered, the protective effect was blocked. The data are expressed as the mean ± SD (n = 6 per group). *Significantly different from the control (p < 0.05); #significantly different from the VILI group (p < 0.05)

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