Fig. 5
From: Evaluation of secondhand smoke effects on CFTR function in vivo
Antioxidants protect against reduced CFTR function by secondhand smoke (SHS) in vitro. a. Representative Ussing chamber electrophysiologic tracing of primary human bronchial epithelial (HBE) cells pretreated with N-acetylcysteine (NAC, 300 μM) for 30 min and exposed to either control room air or SHS for 10 min at room temperature. b. Summary graphs illustrates changes in forskolin (10 μM)-stimulated CFTR activity in HBE cells that was also evident in Isc change following addition of CFTR specific inhibitor, CFTRInh172 (10 μM, (c). n = 6–8, *P < 0.05; **P < 0.005