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Table 4 Detailed information of all datasets used in SMD metaanalysis: eligible GEO datasets, TCGA, qualified publications and our RT-qPCR (represented as Current study). P<0.05 was considered as significant. Annotation: SMDstandard mean deviation, NOnumber, RTqPCRrealtime quantitative polymerase chain reaction. Since no citations were reflected for GSE24709, GSE46729, GSE93300, GSE19945 and GSE74190, websites were the alternatives

From: Downregulation of hsa-microRNA-204-5p and identification of its potential regulatory network in non-small cell lung cancer: RT-qPCR, bioinformatic- and meta-analyses

IDLead authorYearCountrySourcePlatformExperimental typeCitationCancer No.Control No.T valuePvalue
GSE16512Lodes MJ2009USAplasmaGPL8686array[31]3140.0660.057
GSE17681Keller A2009GermanyplasmaGPL9040array[32]1719−1.1040.009
GSE24709Keller A2011GermanyplasmaGPL9040array[33]28192.2890.000
GSE27486Patnaik SK2010USAplasmaGPL11432array[34]22231.6990.518
GSE31568Keller A2011GermanyplasmaGPL9040array[35]32701.5270.363
GSE40738Patnaik SK2012USAplasmaGPL16016array[36]8659−2.5610.125
GSE46729Godrey A2014USAplasmaGPL8786array[37]24240.9550.945
GSE61741Keller A2014GermanyplasmaGPL9040array[38]73944.4270.000
GSE68951Leidinger P2015GermanyplasmaGPL16770array[39]26122.5530.773
PMID:26497897Guo W2015ChinaplasmaNRRT-qPCR[15]12650NR< 0.001
GSE93300Liu X2017ChinaplasmaGPL21576array[40]943.5570.748
GSE2564Lu J2005USAtissueGPL1987array[41]144−0.7310.396
GSE14936Seike M2009USAtissueGPL8879array[42]2626−1.3440.654
GSE15008Tan X2009ChinatissueGPL8176array[43]1871742.8830.000
GSE16025Raponi M2009USAtissueGPL5106array[44]61100.9160.111
GSE18692Puissegur M2009FrancetissueGPL4718array[45]1313−5.0720.617
GSE19945Ohba T2010JapantissueGPL9948array[46]208−1.3050.289
GSE25508Guled M2011FinlandtissueGPL7731array[47]26261.8680.080
GSE29248Ma L2010ChinatissueGPL8179array[48]66−0.4310.474
GSE36681Jang JS2012USAtissueGPL8179array[49]103103−3.2820.001
GSE47525van Jaarsveld MT2013NetherlandstissueGPL17222array[50]1814−1.4990.103
GSE48414Bjaanaes MM2014NorwaytissueGPL16770array[51]15420−5.8910.000
GSE51853Arima C2014JapantissueGPL7341array[52]1265−1.630.103
GSE53882Pu HY2014ChinatissueGPL18130array[53]3971510.1480.933
GSE56036Fujita Y2014JapantissueGPL15446array[54]1427−0.7560.204
GSE63805Robles AI2014USAtissueGPL18410array[55]32300.4490.074
GSE72526Gasparini P2015SwitzerlandtissueGPL20275array[56]6718− 3.9040.000
GSE74190Jin Y2015ChinatissueGPL19622array[57]7244−1.3060.141
GSE102286Mitchell KA2017USAtissueGPL23871array[58]9188−1.0870.003
TCGANRNRNRtissueNRarrayNR99991−3.0550.000
Literature 1Li LX2017ChinatissueNRRT-qPCR[28]3939NR<0.01
Literature 2Xu YZ2018ChinatissueNRRT-qPCR[30]60609.3610.000
Literature 3Wang QC2018ChinatissueNRRT-qPCR[29]727211.028<0.01
Current studyNRNRChinatissueNRRT-qPCRNR125125−3.5070.007