Gene expression pattern analysis using dual-color RT-MLPA and integrative genome-wide association studies of eQTL for tuberculosis suscepitibility

Table 3 Selected SNPs, related genes and corresponding selection strategies

Strategies	SNPs	Related Genes
The expression levels of mRNAs associated with SNPs using eQTL analysis(P < E-05)	107 SNPs (see Additional file 1: Table S4)	-
The 5 SNPs with smallest p values	rs7203246	EEF2K
	rs62292160	ADRA2C
	rs17170200	TPK1
	rs2189164	TACR3
	rs3786247	LIPG
Related genes were involved in the modulation of immune functions or playing a role TB	rs1667908	MBP
	rs7203246	EEF2K
	rs12712986	TTC7A
Related genes interact in a regulatory network	rs4654400	PTPRU
	rs7203246	EEF2K
	rs62292160	ADRA2C
	rs2189164	TACR3
	rs3786247	LIPG
	rs1667908	MBP
	rs17170200	TPK1

The table showed the strategy for screening the SNPs. First, 107 SNPs whose P value < E−05 were selected. In these 107 SNPs, the most differentially expressing 5 SNPs were selected, whose p value was less than E−07. 3 SNPs which played key roles in immune regulation or TB and 7 SNPs involved in the interaction network were select

ISSN: 1465-993X