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Table 2 Genomic alterations associated with targeted therapies

From: Mutation profile of non-small cell lung cancer revealed by next generation sequencing

Gene

Alteration

Targeted therapy

Frequency

Any gene (s)

  

34

EGFR

L858R + E709G

Gefitinib

1

 

Exon 19 deletion

Erlotinib, Gefitinib, Afatinib

12

 

L858R + T790M

Osimertinib

1

 

L858R

Erlotinib, Gefitinib, Afatinib

12

KRAS

G12V

Resistance to Erlotinib and Gefitinib

1

 

G12A

Resistance to Erlotinib and Gefitinib

1

 

G12D

Resistance to Erlotinib and Gefitinib

1

 

Q61H

Resistance to Erlotinib and Gefitinib

1

ERBB2

Insertion

Afatinib, Dacomitinib, Trastuzumab

2

MET

R1004X

Crizotinib

1

 

c.1738 + 1G > T

  

NTRK1

R646C

Entrectinib

1

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Respiratory Research

ISSN: 1465-993X

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